systemic lupus erythematosus

Also know as

SLE

Disease Onset

acute or chronic (seconds to years)

Etiologic Category

autoimmune

Comment

The typical butterfly or malar rash is due to sun-sensitivity and can also be seen in other sun-sensitive dermatologic pathologies, such as pellagra. Symptom frequency for many symptoms taken at disease onset when this data was available; expect higher cumulative frequencies.

Incidence

7 cases per 100,000 person-years

Tests
Wikipedia
References
behavioural
  • anorexia common
  • memory impairment rare
  • psychosis rare
extremities
head
  • nasal ulcer common
  • oral ulcer common
  • rash (patch/plaque, white, mouth) common
labwork
skin
  • hair loss (diffuse) common
  • hair loss (patchy) common
  • rash (annular plaque, red) uncommon
  • rash (bullae) rare
  • rash (macular, red) common
  • rash (nodular, red) uncommon
  • rash (nodular, skin-colored) uncommon
  • rash (nodular, warty) rare
  • rash (papular, hyperkeratotic) uncommon
  • rash (papular, red) common
  • rash (papular, skin-colored) uncommon
  • rash (patch, red) common
  • rash (plaque, hyperkeratotic) uncommon
  • rash (plaque, red) uncommon
  • rash (plaque, warty) rare
  • rash (reticular, red) uncommon
  • rash (worsened by sunlight) common
  • subcutaneous nodule uncommon
  • subcutaneous plaque uncommon
systemic
  • fatigue very common
  • weight loss common
vital signs
  • fever very common
very common (>50%)
  • fatigue
  • fever
  • myalgia
  • arthralgia
  • arthritis (peripheral joint)
common (11-50%)
  • rash (papular, red)
  • weight loss
  • anorexia
  • nasal ulcer
  • oral ulcer
  • rash (worsened by sunlight)
  • coronary artery disease
  • nonbacterial thrombotic endocarditis
  • anemia (decreased production from chronic disease)
  • mitral valve prolapse
  • mitral regurgitation (chronic)
  • rash (macular, red)
  • hair loss (patchy)
  • hair loss (diffuse)
  • rash (patch/plaque, white, mouth)
  • esophageal dysmotility
  • cutaneous small vessel vasculitis
  • synovitis
  • tendinitis / tendinopathy
  • osteoporosis
  • gastric dysmotility
  • Raynaud phenomenon
  • enthesopathy/enthesitis
  • rash (patch, red)
  • peripheral arterial stenosis
  • keratoconjunctivitis sicca
  • xerostomia
cardiac
dermatologic
gastroenterologic
hematologic
nephrologic
neurologic
ophthalmologic
orthopedics
otolaryngologic
respiratory
rheumatologic
vascular